Cell death machinery makes life more robust

Cell death machinery makes life more robust

CED-3, a protein that is essential for programmed cell death, also has an unexpected role in the regulation of non-apoptotic genes during normal development.

Polymeric Gas Separation Membranes: What Makes them Industrially more Attractive?

Robust artificial life via artificial programmed death

We propose a novel approach to self-regenerating continuously-operating systems. Such systems provide best-case solutions in security surveillance or decision making centers. We introduce HADES, a self-regenerating system whose agents acknowledge their “citizenship” or faithfulness to the good of the system and are able to monitor their environment. When agents of HADES find irregularity in the...

Constitutive expression of the machinery for programmed cell death

In the presence of cycloheximide (CHX) to inhibit protein synthesis, a high concentration of staurosporine (STS) induces almost all cells in explant cultures of 8/8 types of newborn mouse organs and 3/3 types of adult mouse organs to die with the characteristic features of apoptosis. Eggs and blastomeres also die in this way when treated with STS and CHX, although they are less sensitive to thi...

Cables1 complex couples survival signaling to the cell death machinery.

Cables1 is a candidate tumor suppressor that negatively regulates cell growth by inhibiting cyclin-dependent kinases. Cables1 expression is lost frequently in human cancer but little is known about its regulation. Here, we report that Cables1 levels are controlled by a phosphorylation and 14-3-3-dependent mechanism. Mutagenic analyses identified two residues, T44 and T150, that are specifically...